業績リスト
■ 最近の原著論文
T. Hata, Y. Hayashi, Y. Hasegawa, M. Iwai, A. Ishii, M. Hasegawa, M. Shigeta, H. Urabe, "Preparation of Tetrazole-fused π-Conjugated Molecules and Their Fluorescence Behavior," Chem. Lett., 48, 662-665 (2019).

G. Sugano, K. Kawada, M. Shigeta, T. Hata, H. Urabe, "Iron-catalyzed δ-selective conjugate addition of methyl and cyclopropyl Grignard reagents to α,β,γ,δ-unsaturated esters and amides," Tetrahedron Lett., 60, 885-890 (2019).

A. Furukawa, T. Hata, M. Shigeta, H. Urabe, "Rh-catalyzed Intramolecular Cyclization of 1-Sulfonyl-1,2,3-triazole and Sulfinate. Concise Preparation of Sulfonylated Unsaturated Piperidines," Tetrahedron Lett., 60, 815-819 (2019).

■ 原著論文
  1. H. Urabe, D. Hideura, and F. Sato, "Asymmetric Synthesis of Bicyclic Ketones Having an Angular Substituent via Ti(II) Alkoxide-Mediated Tandem Cyclization of Tri-substituted Olefinic Substrates," Org. Lett., 2, 381-383 (2000).
  2. T. Hamada, R. Mizojiri, H. Urabe, and F. Sato, "Expedient Construction of Multiple Stereogenic Centers in an Acyclic System via the Addition of Aldehydes, Ketones, and Chiral Imines to an Enyne-Titanium Alkoxide Complex," J. Am. Chem. Soc., 122, 7138-7139 (2000).
  3. D. Suzuki, H. Urabe, and F. Sato, "Asymmetric Synthesis of Baylis-Hillman-Type Allyl Alcohols via a Chiral Acetylenic Ester-Titanium Alkoxide Complex," Angew. Chem. Int. Ed., 39, 3290-3292 (2000).
  4. R. Mizojiri, H. Urabe, and F. Sato, "Generation of a Silylethylene-Titanium Alkoxide Complex. A Versatile Reagent for Silylethylation and Silylethylidenation of Unsaturated Compounds," J. Org. Chem., 65, 6217-6222 (2000).
  5. H. Urabe, R. Nakajima, and F. Sato, "A Facile Preparation of exo-Cyclic Conjugated Dienes Fused to Lactams or Lactones via Intramolecular Coupling of Acetylenes and Their Behavior in Diels-Alder Reactions," Org. Lett., 2, 3481-3484 (2000).
  6. C. Delas, H. Urabe, and F. Sato, "Titanium-Mediated Intramolecular Cyclization of Tethered Propargyl Alcohol Derivatives. Access to Exocyclic Bis-Allenes and Cyclobutene Derivatives," Tetrahedron Lett., 42, 4147-4150 (2001).
  7. D. Suzuki, H. Urabe, and F. Sato, "Metalative Reppe Reaction. Organized Assembly of Acetylene Molecules on Titanium Template Leading to a New Style of Acetylene Cyclotrimerization," J. Am. Chem. Soc., 123, 7925-7926 (2001).
  8. C. Delas, H. Urabe, and F. Sato, "Remarkably Facile, Unidirectional Isomerization of Titanated Vinylallenes to Cyclobutenyltitanium Compounds. A Practical Construction of a Cyclobutene Framework," J. Am. Chem. Soc., 123, 7937-7938 (2001).
  9. R. Nakajima, H. Urabe, and F. Sato, "Intramolecular Coupling of Vinyl Ether and Olefins or Acetylenes with Ti(II) Reagent. Regio- and Stereoselective Vinyltitanation of Carbon-Carbon Multiple Bonds," Chem. Lett., 4-5 (2002).
  10. H. Urabe, K. Kusaka, D. Suzuki, and F. Sato, "Chiral 1,3-Butadiene-2-carboxylates for an Efficient Asymmetric Diels-Alder Reaction," Tetrahedron Lett., 43, 285-289 (2002).
  11. C. Delas, H. Urabe, and F. Sato, "Site-selective Mono-titanation of Conjugated Diynes with a Ti(II) Alkoxide Reagent. Concise Preparation of Stereo-Defined Enynes and Dienynes," Chem. Commun., 272-273 (2002).
  12. C. Delas, H. Urabe, and F. Sato, "Stereoselective One-pot Preparation of 1,2,4,5-Tetraalkylidene- and 1,4-Dialkylidenecyclohexanes," Chem. Commun., 820-821 (2002).
  13. D. Suzuki, R. Tanaka, H. Urabe, and F. Sato, "Selective Syntheses of Metalated Pyridines from Two Different Unsymmetrical Acetylenes, a Nitrile, and a Titanium(II) Alkoxide," J. Am. Chem. Soc., 124, 3518-3519 (2002).
  14. M. Narita, H. Urabe, and F. Sato, "Sulfur-Functionalized Olefins for Titanacycle Formation: Tandem Asymmetric Cyclization and the Pummerer Reaction Based on Sulfoxides Promoted by Titanium(II)-to-Titanium(IV) Relay," Angew. Chem. Int. Ed., 41, 3671-3674 (2002).
  15. R. Tanaka, Y. Nakano, D. Suzuki, H. Urabe, and F. Sato, "Selective Preparation of Benzyltitanium Compounds by the Metalative Reppe Reaction. Its Application to the First Synthesis of Alcyopterosin A," J. Am. Chem. Soc., 124, 9682-9683 (2002).
  16. R. Tanaka, S. Hirano, H. Urabe, and F. Sato, "Concise and Stereoselective Synthesis of Enamides and Dienamides by Titanium-Mediated Coupling Method," Org. Lett., 5, 67-70 (2003).
  17. H. Urabe, D. Suzuki, and F. Sato, "Generation of an Acetylene-titanium Alkoxide Complex. Preparation of (Z)-1,2-Dideuterio-1-(trimethylsilyl)-1-hexene," Org. Synth., 80, 120-128 (2003).
  18. H. Urabe, D. Suzuki, M. Sasaki, and F. Sato, "Enol Ester as an Olefinic Partner in Enyne Cyclization. A Novel Tandem Cyclization to Stereo-defined Bicyclo[3.3.0]octenes," J. Am. Chem. Soc., 125, 4036-4037 (2003).
  19. H. Urabe, K. Mitsui, S. Ohta, and F. Sato, "Titanium Alkoxide Complex of Functionalized Conjugated Dienes. A Versatile Bis-anionic Template for Stereoselective Construction of Carbon Frameworks," J. Am. Chem. Soc., 125, 6074-6075 (2003).
  20. K. Mitsui, T. Sato, H. Urabe, and F. Sato, "Stereoselec
  21. tive Construction of Acyclic Carbon Chains via One-pot Coupling Process Based on Alkenyloxazoline-Titanium Complexes," Angew. Chem. Int. Ed., 43, 490-492 (2004).
  22. S. Hirano, R. Tanaka, H. Urabe, and F. Sato, "Practical Preparation of N-(1-Alkynyl)sulfonamides and Their Remote Diastereoselective Addition to Aldehydes via Titanation," Org. Lett., 6, 727-729 (2004).
  23. R. Tanaka, M. Sasaki, F. Sato, and H. Urabe, "A Novel Propargyltitanation of Acetylenes. Heteroatom Substituent-Dependent Manifold in Intermolecular Coupling of Allene and Acetylene," Tetrahedron Lett., 46, 329-332 (2005).
  24. K. Fukuhara and H. Urabe, "Iron-Catalyzed 1,6-Addition of Aryl Grignard Reagents to 2,4-Dienoates and -Dienamides," Tetrahedron Lett., 46, 603-606 (2005).
  25. D. Suzuki, Y. Nobe, Y. Watai, R. Tanaka, Y. Takayama, F. Sato, and H. Urabe, "Facile Preparation of Various Heteroaromatic Compounds via Azatitanacyclopentadiene Intermediates," J. Am. Chem. Soc., 127, 7474-7479 (2005).
  26. R. Tanaka, A. Yuza, Y. Watai, D. Suzuki, Y. Takayama, F. Sato, and H. Urabe, "One-Pot Synthesis of Metalated Pyridines from Two Acetylenes, a Nitrile, and a Titanium(II) Alkoxide," J. Am. Chem. Soc., 127, 7774-7780 (2005).
  27. Y. Nobe, K. Arayama, and H. Urabe, "Air-Assisted Addition of Grignard Reagents to Olefins. A Simple Protocol for Three-Component Coupling Process Yielding Alcohols," J. Am. Chem. Soc., 127, 18006-18007 (2005).
  28. S. Hirano, Y. Fukudome, R. Tanaka, F. Sato, and H. Urabe, "Practical Preparation of N-(1-Alkynyl)sulfonamides and Their Synthetic Utility in Titanium Alkoxide-Mediated Coupling Reactions," Tetrahedron (Symposium-in-Print), 62, 3896-3916 (2006).
  29. H. Urabe, D. Shikanai, K. Arayama, T. Sato, and R. Tanaka, " Electrophile-triggered Assembly of Metal Enamides and Allyl Grignard Reagent in One Pot. Novel Nucleophilic Double Allylation of Azadienes," Chem. Lett., 36, 556-557 (2007).
  30. H. Naito, T. Hata, and H. Urabe, "Facile Preparation of N-Protected 2-Alkylidene-1,3-imidazolidines," Tetrahedron Lett., 49, 2298-2301 (2008).
  31. Y. Fukudome, H. Naito, T. Hata, and H. Urabe, "Copper-Catalyzed 1,2-Double Amination of 1-Halo-1-alkynes. Concise Synthesis of Protected Tetrahydropyrazines and Related Heterocyclic Compounds," J. Am. Chem. Soc., 130, 1820-1821 (2008).
  32. R. Tanaka, H. Sanjiki, and H. Urabe, "Yttrium-Mediated Conversion of Vinyl Grignard Reagent to a 1,2-Dimetalated Ethane and Its Synthetic Application," J. Am. Chem. Soc., 130, 2904-2905 (2008).
  33. S. Okada,† K. Arayama,† R. Murayama, T. Ishizuka, K. Hara, N. Hirone, T. Hata, and H. Urabe, "Iron Catalyst-Switched Selective Conjugate Addition of Grignard Reagents. α,β,γ,δ- Unsaturated Amides as Versatile Templates for Asymmetric Three-Component Coupling Process," Angew. Chem. Int. Ed., 47, 6860-6864 (2008). †Equal contribution
  34. T. Hata, N. Hirone, S. Sujaku, K. Nakano, and H. Urabe, "Iron-Mediated Intramolecular Metallative Cyclization of alpha,beta-Unsaturated Esters and Amides. Versatile One-Pot Preparation of Bicyclic Ketoesters," Org. Lett., 10, 5031-5033 (2008).
  35. D. Shikanai, H. Murase, T. Hata, and H. Urabe, "Rh-catalyzed Isomerization and Intramolecular Redox Reaction of Alkynyl Ethers Affording Dihydropyrans and Ketoolefins," J. Am. Chem. Soc., 131, 3166-3177 (2009).
  36. T. Hata, R. Bannai, M. Otsuki, and H. Urabe, "Iron-Catalyzed Regio-and Stereoselective Substitution of γ,δ-Epoxy-α,β-unsaturated Esters and Amides with Grignard Reagents," Org. Lett., 12, 1012-1014 (2010).
  37. H. Naito, T. Hata, and H. Urabe, "Selective Deprotection of Methanesulfonamides to Amines,"Org. Lett., 12, 1228-1231 (2010).
  38. Naoki Hirone, Hiroaki Sanjiki, Ryoichi Tanaka, Takeshi Hata, and Hirokazu Urabe, "Acceleration of the Substitution of Silanes with Grignard Reagents by Using either LiCl or YCl3/MeLi," Angew. Chem. Int. Ed., 49, 7762-7764 (2010).
  39. Yuzo Kato, Dinh Hoang Yen, Yasuhiro Fukudome, Takeshi Hata, and Hirokazu Urabe, "Aryl(sulfonyl)amino Group: A Convenient and Stable yet Activated Modification of Amino Group for Its Intramolecular Displacement," Org. Lett., 12, 4137-4139 (2010). [Highlighted in Nature Chemistry published online September 10, 2010]
  40. Yun Taek Oh, Kousuke Senda, Takeshi Hata, Hirokazu Urabe, "Rh-catalyzed intramolecular debenzylative cyclization of amines. Butyrolactams from benzylamines having a chloroacetylene moiety," Tetrahedron Lett., 52, 2458-2461 (2011).
  41. Masahito Yamagishi, Ken Nishigai, Takeshi Hata, and Hirokazu Urabe, "Nucleophilic Addition of Sulfonamides to Bromoacetylenes: Facile Preparation of Pyrroles," Org. Lett., 13, 4873-4875 (2011).
  42. Takeshi Hata, Shiro Sujaku, Naoki Hirone, Kirihiro Nakano, Junsuke Imoto, Haduki Imade, and Hirokazu Urabe, "Iron-Mediated and -Catalyzed Metallative Cyclization of Electron Withdrawing Group-substituted Alkynes and Alkenes with Grignard Reagents," Chem. Eur. J., 17, 14593-14602 (2011).
  43. Masahito Yamagishi,† Jun Okazaki,† Ken Nishigai, Takeshi Hata, and Hirokazu Urabe, "Additive-free Nucleophilic Addition of Imidazolines and Imidazoles to Haloacetylenes," Org. Lett., 14, 34-37 (2012) . †Equal contribution
  44. Takeshi Hata, Haduki Imade, and Hirokazu Urabe, "Four Nucleophilic Additions to Alkenynedioic Acid Derivatives in Tandem; Efficient One-pot Synthesis of Bicyclo[4.2.0]octenols," Org. Lett., 14, 2450-2453 (2012).
  45. Masahito Yamagishi, Ken Nishigai, Azusa Ishii, Takeshi Hata, and Hirokazu Urabe, "Facile Preparation of Indoles and 1,2-Benzothiazine 1,1-Dioxides via Nucleophilic Addition of Sulfonamides to Bromoacetylenes Followed by Pd-Catalyzed Cyclization," Angew. Chem. Int. Ed., 51, 6471-6474 (2012).
  46. Takeshi Hata, Satoshi Iwata, Shumpei Seto, and Hirokazu Urabe, "Iron-Catalyzed Synthesis of Allenes from 2-Alken-4-ynoates and Grignard Reagents," Adv. Synth. Catal., 354, 1885-1889 (2012).
  47. Satoshi Iwata, Takeshi Hata, and Hirokazu Urabe, "Synthesis of tert-Butyl Peroxyacetals from Benzyl, Allyl, or Propargyl Ethers via Iron-Promoted C-H Bond Functionalization," Adv. Synth. Catal., 354, 3480-3484 (2012).
  48. Satoshi Iwata, Masato Senoo, Takeshi Hata, and Hirokazu Urabe, "Synthesis of S-Aryl Arenethiosulfonates from N,N-Di(arenesulfonyl)hydrazines: Reduction of Sulfonyl Chlorides with an Organic Reagent," Heteroatom Chem.,24, 336-344 (2013).
  49. Takeshi Hata, Takuya Nakada, Yun Taek Oh, Naoki Hirone, and Hirokazu Urabe, "Iron-Catalyzed Regio- and Stereoselective Conjugate Addition of Aryl-Grignard Reagents to α,β,γ,δ-Unsaturated Sulfones and Its Synthetic Application," Adv. Synth. Catal., 355, 1736-1740 (2013).
  50. Hirohiko Murase, Kosuke Senda, Masato Senoo, Takeshi Hata, and Hirokazu Urabe, "Rhodium-catalyzed Intramolecular Hydroarylation of 1-Halo-1-alkynes. Regioselective Synthesis of Semihydrogenated Aromatic Heterocycles," Chem.-Eur. J. 20, 317-322 (2014).
  51. Takeshi Hata, Hideyuki Gotoh, Tomofumi Yokomizo, and Hirokazu Urabe, "Iron-catalyzed 1,6-Selective Addition of Aryl Grignard Reagent to tert-Butyl (Z)-5-Phenyl-3-hexenoate," Org. Synth. 91, 307-321 (2014).
  52. Tomoya Mizumori, Takeshi Hata, and Hirokazu Urabe, "Alkylation of Pyridines at Their 4-Position with Stylenes plus an Yttrium Reagent or Benzyl Grignard Reagents,” Chem.-Eur. J. 21, 422-426 (2015).
  53. Masahito Yamagishi, Azusa Ishii, Takeshi Hata, and Hirokazu Urabe, "Facile Preparation of 1,2-Dihydroisoquinolines from N-Benzylsulfonamides and Bromoacetylenes," Heterocycles 90, 847-856 (2015). (Current Special Issue: Isao Kuwajima's Special Issues)
  54. Masato Senoo, Ayana Furukawa, Takeshi Hata, and Hirokazu Urabe, "Rh-catalyzed Intramolecular C-H Bond Activation with Triazoles. Preparation of Stereo-defined Pyrrolidines and Other Related Cyclic Compounds,” Chem.-Eur. J. 22, 890-895 (2016).
■ 総説・著書
  • 占部弘和、"共役ジ-、テトラ-、およびヘキサイン-チタン錯体の構造と反応"、Organometallic News, 55 (2000)
  • F. Sato, H. Urabe, and S. Okamoto, "Synthetic Reactions Mediated by a Ti(O-i-Pr)4 / 2 i-PrMgX Reagent," Synlett, 753-775 (2000)
  • 占部弘和、"有機合成における華やかな金属試薬・チタン"、ファルマシア、36, 612-613 (2000)
  • F. Sato, H. Urabe, and S. Okamoto, "Synthesis of Organotitanium Complexes from Alkenes and Alkynes, and Their Synthetic Application," Chem. Rev., 100, 2835-2886 (2000)
  • F. Sato and H. Urabe, "Chapter 3. Hydromagnesiation of Alkenes and Alkynes" in Grignard Reagents - New Developments, H. G. Richey, Jr., Ed., Wiley: Chichester, pp. 65-105 (2000)
  • H. Urabe and F. Sato, "Chapter 15. Titanium(IV) Lewis Acids" in Lewis Acids in Organic Synthesis, H. Yamamoto, Ed., Wiley-VCH: Weinheim, Vol. 2, pp. 653-798 (2000)
  • 占部弘和、"チタナサイクルによる有機合成の新しい幕開け"、有機合成化学協会誌、59, 438-439 (2001)
  • 占部弘和、"有機合成を指向するチタナサイクルの開発と利用-最近の動向-"、化学工業、52, 913-918 (2001)
  • F. Sato and H. Urabe, "Chapter 9. Titanium(II) Alkoxide in Organic Synthesis" in Titanium and Zirconium in Organic Synthesis, I. Marek, Ed., Wiley-VCH: Weinheim, pp. 319-354 (2002)
  • H. Urabe, "New Synthetic Reactions Mediated by Organometallic Compounds" in My Favorite Organic Synthesis, 有機合成化学協会・竜田邦明・福山透編、化学同人、pp. 244-245 (2002)
  • H. Urabe and F. Sato, "Titanocene (Cp2Ti(II)" in Electronic Encyclopedia of Reagents for Organic Synthesis, L. A. Paquette, Ed., Wiley: Chichester (2003)
  • 西山、石原、村上、占部、中村、柴田、八谷、"20年後に有機合成はどこに行くのか"、有機合成化学協会誌、62, 933-938 (2004)
  • 占部弘和、"4族(Ti,Zr)メタラサイクルを経るヘテロ環化合物の合成法-アセチレン、オレフィン、およびヘテロ不飽和化合物の環化反応"、有機合成化学協会誌、63, 102-111 (2005)
  • 占部弘和、"メタラサイクルをテンプレートとする多成分連結反応の開発"、化学工業、57, 757-762 (2006)
  • 占部弘和、"バイオ系のための基礎化学問題集"、'第10章 アルケン・アルキン/第11章 官能基変換'、講談社サイエンティフィク, pp. 132-143 (2008)
  • 占部弘和、秦猛志、"医薬・生体機能分子の未来指向型合成法の開発"、バイオ研究のフロンティア3・医療・診断をめざす先端バイオテクノロジー、関根光雄・編、工学図書、pp. 118-130 (2009)
  • Hirokazu Urabe and Fumie Sato, "Titanocene (Cp2Ti(II)" in Encyclopedia of Reagents for Organic Synthesis, 2nd ed.; L. A. Paquette, D. Crich, P. L. Fuchs, G. A. Molander, Eds., Wiley: Chichester, Vol. 12, pp. 9590-9595 (2009)
  • 占部弘和、秦猛志、"第4章 芳香族化合物 -医薬品化学への展開"、生命理工系のための大学院基礎講座-有機化学、湯浅英哉・編、東京工業大学出版会・工学図書、pp. 67-90 (2011)
  • 秦 猛志、"鉄試薬による官能性炭素-炭素多重結合の制御を利用する新規合成手法の開発"、有機合成化学協会誌、72, 972-982 (2014)